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Current technical topics

We are developing synthesis of intermediates of 19-nor-Vitamin D3 type compounds.

Recently, much attention has been paid to compounds of 2-alkylidene-19-nor-Vitamin D, especially compounds with a small alkyidene, especially methylene, group because those compounds do not interfere with the vitamin D receptor. Recently, we developed a synthetic method for an important intermediate "19-nor-VD A ring synthon". The compound "19-nor-VD A ring synthon 2" is an important intermediate of 2-methylene-19-nor-Vitamin D which has a methylene moiety at 2 position. "19-Nor-VD A ring synthon 1" can be transformed to various types of 2-position substituted 19-nor-Vitamin D compounds through function transformation of the methylene group.